Senior Digital Twin ML Engineer

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Summary

Location

San Francisco, United States

Work

Full-time

Experience

Senior

Key Benefits
Equity Grants

About this Job

About Grafton Sciences

We’re building AI systems with general physical ability — the capacity to experiment, engineer, or manufacture anything. We believe achieving this is a key step towards building superintelligence. With deep technical roots and real-world progress at scale (e.g., a $42M NIH project), we’re pushing the frontier of physical AI. Joining us means inventing from first principles, owning real systems end-to-end, and helping build a capability the world has never had before.

About the Role

We’re seeking a Senior Digital Twin ML Engineer to build high-fidelity digital twins of robotic, electromechanical, and experimental systems. You’ll design model-identification pipelines, calibration routines, dynamic-model learning systems, and multi-scale representations that enable accurate predictive simulation and closed-loop interaction with RL, planning, and control stacks. This role blends physics intuition, ML modeling, and hands-on experimentation to ensure digital twins remain stable, accurate, and continuously updated as real systems evolve.

Responsibilities

  • Develop model-identification pipelines, parameter fitting routines, and adaptive calibration systems for digital twins.
  • Build ML-based dynamic models, multi-scale physics approximators, and hybrid simulation frameworks.
  • Ensure twin fidelity, stability, and cross-version consistency as real systems change or new data arrives.
  • Collaborate with simulation, RL, controls, and agent systems teams to integrate digital twins into learning and decision-making workflows.

Qualifications

  • Strong experience building or calibrating digital twins, dynamic models, or data-driven physics models.
  • Familiarity with system identification, time-series modeling, physical parameter estimation, and stability/fidelity considerations.
  • Ability to blend physics, machine learning, and experimental data into robust predictive models.
  • Comfortable working across ML, simulation tools, and physical hardware interfaces in a fast-moving research and engineering environment.

Above all, we look for candidates who can demonstrate world-class excellence.

Compensation

We offer competitive salary, meaningful equity, and benefits.

About the Company

Grafton Sciences logo

Grafton Sciences

Privately Held
System IntegrationRobotics Software & AIHealthcare & Life Sciences

Grafton Biosciences is a biotechnology startup based in South San Francisco. The company focuses on developing innovative solutions to address diseases by integrating computation, hardware, and advanced biology. Grafton aims to make biology computable through a closed-loop system that targets various diseases, particularly in the field of early cancer detection. The company specializes in early disease detection, diagnostics, and therapeutics. It employs advanced techniques such as multi-omics sensing and at-home diagnostic capabilities to enhance the accuracy of disease identification. Grafton utilizes computational chemistry and molecular modeling to design and optimize its solutions, closely linking computational work with experimental biology to accelerate discovery and development. With $40 million in funding, Grafton Biosciences is building a team of skilled engineers and scientists to support its mission of extending healthy human lifespans and driving health innovations.

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